The course aims to provide extensive knowledge in genetic alternations and clinical management of hereditary cancers, molecular technologies of genomic tests and principles in genetic counselling.

A total of five hereditary cancer diseases including breast, ovarian, colorectal, pancreatic and prostate cancers will be covered comprehensively by prestigious oversea and local speakers. An interactive case sharing session and next-generation sequencing (NGS) laboratory walkthrough are designed for the participants at the end of the course to enhance their learning experience.

This course is recommended for clinical and medical oncologists, clinical geneticists, genetic counsellors, breast surgeons, gynaecologists, gastrointestinal surgeons, urological surgeons, oncology nurses, pathologists, medical laboratory technologists and scientists.

– Introduction to hereditary cancer diseases
- Hereditary cancer diseases and genetics, inheritance mode and risk factors
- Types of alterations, symptoms and family history for referral and consent

– Overview of hereditary cancer genetic testing
- Scope and selection of hereditary gene tests, and how to take family history
- Methods to detect genetic variations and germline gene test case studies

– Understanding genetic test reports
- Lab selection, pathogenicity of variants and test report interpretation
- Management of patients undergoing genetic testing

– Hereditary breast cancer & genetic counseling
- Common mutations (e.g. BRCA1/2, PTEN, p53, HRD genes)
- Referral criteria, risk assessment and genetic counselling

 – Clinical management of hereditary breast cancer from a surgeon’s view
- Prevalence in HK, common genetic alterations and case reports
- Screening, chemoprevention, prophylactic measures & surgery

 – Precision oncology medicines in hereditary breast cancer
- Somatic genomic test interpretation
- Common targeted drugs (e.g. TKi, CDK4/6i, mTORi, PIK3CAi, PARPi, ICI)

 – Hereditary ovarian cancer & genetic counselling
- Common mutations (e.g. BRCA1/2, MLH1, MSH2, MSH6, PMS2, STK11, HRD)
- Shared risks associated with hereditary breast cancer
- Referral criteria for testing and genetic counselling advic

 – Clinical management of hereditary ovarian cancer
- Screening, clinical management and risk reduction in carriers
- Emerging new therapeutics (e.g. PARP inhibitors, ICIs)

Management and recommendations for carriers
– Hereditary colorectal cancer & genetic counselling

– Clinical management of hereditary colorectal cancer
- Risk reduction and management for carriers
- Common and emerging new therapeutics (e.g. EGFRi,  mAb, VEGFi, KRASi, ICIs)

– Pancreatic cancer – clinical management & hereditary susceptibility
- Genetic alterations (e.g. BRCA1/2, P16, STK11, PALB2, MMR, PRSS1/TRY1)
- Hereditary pancreatitis, common and emerging new therapeutics

 – Prostate cancer: The genetics of disease risk and management
- Genetic alterations (e.g. BRCA1/2, ATM, RAD51, BRIP1, PALB2, CHEK2, HOXB13)
- Evolving germline testing and emerging new treatment (e.g. PARPi, ICI)

 – Germline genomic testing as cross-over indications for cancel treatments
- Practical aspects and analyses of NGS, SNV, Indel, CNV, LGR and MLPA
- AMP/ACMG guidelines and interpretation of germline tests

– Laboratory workflow in clinical genomic testing by NGS
- NGS by Ion torrent and Illumina platforms, and quality assurance tests
- Sample preparation and library preparation

 – Interactive session in real life case sharing
- Sharing of interesting clinical cases
- Clinical interpretation of genetic disorders in patients and family members

-Useful examples in hereditary cancers in HK

-What do hereditary cancer patients and thier family members need to know?

-Technological advances in whole exome sequencing (WES)
- Trend in technology development for germline testing in hereditary cancers

Credits

• CME points obtained from the following colleges through Hong Kong Academy of Medicine (Please refer to the leaflet for the details of CME point allocation):
  • Hong Kong College of Radiologists
  • The Hong Kong College of Obstetricians and Gynaecologists
  • Hong Kong College of Physicians
  • The College of Surgeons of Hong Kong
  • The Hong Kong College of Pathologists
  • Hong Kong College of Paediatricians
  • Hong Kong College of Community Medicine
  • The Hong Kong College of Family Physicians
• 14.5 CNE points from The Nursing Council of Hong Kong
• 12 CPD points:
  MLT Board CPD Activity Code/Point – 05200611/12

Award

A Statement of Attendance will be issued to participants who achieved the class attendance of 70%

Days / Time

• Saturday, 2:00pm - 6:00pm

Venue

• Admiralty Learning Centre

Course Fee

• Course Fee : HK$6000

Applicants shall have attained

1.  a Bachelor Degree in Biology, Medicine or related disciplines

OR

2. 3 years or above work experience in healthcare related areas.

Application Form Download Application Form

Enrolment Method

Applicants should submit:

1. Duly completed HKU SPACE application form;

2. Copies of academic certificates and results slips; and

3. A copy of HKID card or passport.

All documents should be sent to the following address:

College of Life Sciences and Technology

HKU SPACE

13/F Fortress Tower

250 King’s Road

North Point

Hong Kong

(Attn: Winnie Choi)

or by email to winnie.choi@hkuspace.hku.hk